recently, specific attention has been paid to aptamers, short dna or rna, as a tool for cancer diagnosis and therapy. in the present study mcs nanogels were prepared by myristate: chitosan at 1:9 ratio and were characterized by several techniques. a selected ssdna aptamer(apt) capable of detecting lncap cells was linked to myristilated chitosan nanogels (apt-mcs) by glutaraldehyde and loaded wi...

pluronic based nano-particulate systems are innovative platforms for delivery of anti-cancer agents. these systems due to their pharmacological properties and suitable physicochemical characteristics are great opportunity for development cancer therapeutics. this mini-review tries to provide a more detailed overview on the currently available pluronic based drug delivery systems. in the section...

glioma, as a primary tumor of central nervous system, is the main cause of death in patients with brain cancer. therefore, development of an efficient strategy for treatment of glioma is worthy. the aim of the current study was to develop a srl peptide-coated dendrimer as a novel dual gene delivery system for targeting the lrp receptor, an up-regulated gene in both bbb and glioma cells. to perf...

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Objective(s): Nanocarriers are drug delivery vehicles, which have attracted the attention of researchers in recent years, particularly in cancer treatment. The encapsulation of anticancer drugs using protein nanocages is considered to be an optimal approach to reducing drug side-effects and increasing the bioavailability of anticancer drugs. Epirubicin (EPR) is an active chemotherapeutic medica...

objective(s): one applications of nanotechnology is in the area of medicine which is called nanomedicine. primary instruments in nanomedicine can help us to detect diseases and used for drug delivery to inaccessible areas of human tissues. an important issue in simulating the motion of nanoparticles is modeling blood flow as a newtonian or non-newtonian fluid. sometimes blood flow is simulated ...